Wxternary is a set of python scripts that can be used to plot data on a ternary diagram. Ternary phase diagram a pseudoternary tutorial youtube. There is a solution which involves viewing the figure from below, but ill leave that for another question. The potential drug vitamin e was loaded in the oil phase. Short oil hydrocarbon chains result in deep organic phase insertions into the interface membrane. Ternary phase diagrams were designed to determine the microemulsion. The model drug vitamin e was loaded in the oil phase. Preparation of nano and microemulsions using phase. If, like me, you find these difficult, you can get a quick tutorial via the phase diagram. Which software is most suitable in preparing ternary phase. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. Microemulsion ciclopirox olamine pseudoternary phase diagram.
A ternary phase diagram is used to determine the composition of the microemulsion and the proportion of the oil phase, surfactant, and cosurfactant. The pseudo ternary phase diagrams were developed by origin software version 2018b. Preparation and evaluation of tretinoin microemulsion based on pseudoternary phase diagram eskandar moghimipour 1,2, anayatollah salimi 1,2, fatemeh leis 2 1 nanotechnology research center, jundishapur university of medical sciences, ahvaz, iran. Doptimal design and development of microemulsion based. Formulation design of microemulsion collector based on.
Chemical method, especially microemulsion flooding, plays an important role in enhanced oil recovery technique due to its. Gibbs phase diagrams can be used to show the influence of changes in the volume. It is the boundary line around that singlephase region. The relative amounts of these three components can be represented in a ternary phase diagram. To understand the app you also have to understand ternary phase diagrams. This research was aimed to characterize microemulsion systems of isopropyl palmitate ipp, water, and 2. It is the point where all three phases in a ternary diagram are partially soluble in each other. Microemulsion phase relationships in the system sodium dodecyl. This software will generate the experimental points for diagram construction. Tutorial modules for the study of phase equilibrium diagrams william g. A hypothetical ternary phase space diagram made up of metals a, b, and c is shown in fig. Design and characterization of microemulsion systems for. Ternary phase diagram that shows the 3phase region.
It graphically depicts the ratios of the three variables as positions in an equilateral triangle. Using algebraic geometry to describe boundaries of microemulsion. The pseudoternary phase diagrams for the microemulsion systems. Formulation and development of microemulsion and smedds akshay r. Smith department of ceramic engineering university of missourirolla abstract understanding and interpreting phase equilibrium diagrams is an essential skill for materials engineers. A series of ternary systems consisting of three components lemon oil, tween 20 or 80 and water were prepared at different ratios via gentle agitation by the phase inversion composition method involving the spontaneous formation of microemulsion.
Isopleth through hypothetical ternary phase diagram at a constant. Microemulsion how to construct ternary phase diagram anyone provide step by step tutorial. As quaternary phase diagram four component system is time consuming and difficult to interpret, pseudo ternary phase diagram is often constructed to find the different zones including microemulsion zone, in which each corner of the diagram represents 100% of the particular component. A fundamental reason for the uses of these systems is that a microemulsion phase sometimes has an ultralow interfacial. Microemulsion how to construct ternary phase diagram anyone provide step by. Minitab15 software was used for experimental design and the evaluation of the effect of variables on responses. Which software is most suitable in preparing ternary phase diagrams in microemulsions. Formulation and characterization of microemulsion system. A ternary phase diagram plotting software for microemulsion fuels. Construction of pseudoternary phase diagram is an important tool for screening of selfdispersible formulation components and to assess the effect of different. Preparation and evaluation of tretinoin microemulsion based on pseudo ternary phase diagram eskandar moghimipour 1,2, anayatollah salimi 1,2, fatemeh leis 2 1 nanotechnology research center, jundishapur university of medical sciences, ahvaz, iran. Preparation and evaluation of tretinoin microemulsion.
Once the proportion is determined, a similar microemulsion can be produced. Microemulsion domains are usually characterized by constructing ternaryphase diagrams. Microemulsion how to construct ternary phase diagram anyone provide step by step. Mpde practical surfactants science prof steven abbott. As shown, the area of the microemulsion in the pseudo ternary phase diagram is significantly affected by the chain length of the cosurfactant. However, the situation of petroleum industries in many countries needs much concern in improving the oil recovery technique. Effect of polyherbal microemulsion on staphylococcus. This diagram contains two binary eutectics on the two visible faces of the diagram, and a third binary eutectic between elements b and c hidden on the back of the plot. Any cosurfactant used are usually grouped together with the surfactant at a fixed ratio and treated as a pseudocomponent. Inhouse ad hoc software was created according to the proposed concept. Phase behaviour of microemulsion the phase behaviour of simple microemulsion system composing oil, water and surfactant can be studied with the aid of ternary phase diagram. Characterization of microemulsion structures in the pseudoternary.
Explore surfactant phase diagrams with a powerful set of apps. Enlargement of nanoemulsion region in pseudoternary. My free book expands on the content in practical surfactants but is. Sigma plot software was applied for providing tertiary phase diagrams.
This page helps you map microemulsion ternary phase diagrams that have been estimated from basic surfactant properties and formulation conditions. Ternary phase diagram a pseudoternary tutorial chemix school v7. Using these data, micellar structure maps were prepared for. Figure 5 shows the pseudoternary phase diagram with the area inside the frame assigned on the phase diagram showing the microemulsion region. The below shows a hypothetical ternary phase diagram of a microemulsion. The way in which i draw the surface plot in ternpcolor makes it hard to use negative values.
Uses a simulation to show how ternary phase diagrams are interpreted. Another important variable that influences the shape of the ternary phase diagram is the length of the surfactant tail l. The algorithm includes a method that resolves the incompatibilities between hld and oilwater ratios. Microemulsion in the present study formed spontaneously at ambient temperature when their. Construction of pseudoternary phase diagram and its evaluation. Phase diagrams for micellar systems are discussed in this chapter kahlweitstrey, 1985. Doptimal design and development of microemulsion based transungual drug delivery formulation of ciclopirox olamine for treatment of onychomycosis, p. How can i construct pseudoternary phase diagram to form. Ternary phase diagram basics interactive simulation.
Microemulsions are usually characterised by ternary phase diagrams, which three edges are the components of a microemulsion, namely, oil, water and surfactant. Can anyone help me to construct a ternary phase diagram for. Can anyone recommend me some phase diagram software. To deliver 2,3,5,6tetramethylpyrazine tmp in a relatively large dose through a transdermal route and facilitate the practical application of microemulison in transdermal drug delivery. To investigate concentration range of components for the existing boundary of mes, pseudoternary phase diagrams were constructed using the water titration method. Which software is most suitable in preparing ternary phase diagrams. Tretinoin, phase diagram, microemulsion, differential scanning calorimetry.
The singlephase boundary line is found on any section that. Pseudoternary phase diagram of microemulsion composed. Turbidity of the samples would indicate formation of a coarse emulsion, whereas a clear isotropic solution would indicate the formation of a microemulsion. Characterization of microemulsion structures in the. The trend of growing interest in alternative source of energy focuses on renewable products worldwide. The results showed that the wo microemulsion were located mostly at the surfactant mixtures apex and protruding towards the wateroil axis. Pseudoternary phase diagram construction to investigate concentration range of components for the existing boundary of mes, pseudoternary phase diagrams were constructed using the water titration method. The effects of different surfactants pure and mixed on the mixing diagrams. This is for a single phase, three component system. Phase diagrams of wo microemulsion stabilised by non.
This algorithm will be described in detail in upcoming articles. Comparison of ow and ilw microemulsion systems as potential. Experimental design is an excellent tool to analyze and optimize the. Microemulsion, ciclopirox olamine, pseudoternary phase diagram. The phase behaviour and nano and microemulsion formation of the ternary mixtures prepared were. Phase diagram of the microemulsion the microemulsion is treated as a pseudoternary system with oil, surfactant, and aqueous components. Three components are the basic requirement to form a microemulsion. The clear formulation represents the microemulsion region and hence the % oil mix, % s mix and % water sufficient to produce a clear formulation at the corresponding stages, were taken to develop a pseudo ternary phase diagram of a particular s mix ratio. Ternary phase diagram software free download ternary. The phase diagram explorer allows you to visualise what happens when you or perhaps your customer travel a dilution path through phase diagram space. Ternary phase diagram basics interactive simulation youtube. The influence of drug loading level on the phase diagram was also determined.
The use of pseudoternary phase diagrams to locate the microemulsion region will be described and the compositions of the template will be suggested. Pseudoternary phase diagrams of a drug delivery system. Throughout the article, two distinct gels, made of two different microemulsion droplets r. Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitatewaterbrij 97. Ternary diagrams have been constructed for 3 specific microemulsion systems showing the effects of salinity and cosurfactant on phase behavior, viscosity, resistivity, optical birefringence, and interfacial tension. Ternary phase diagrams institute for advanced study. I have some problems representing microemulsion phase diagrams. Ternary phase diagram can be represented in a triangular format, in which each coordinate represents one component of microemulsion with 0100% concentration in the increment of 10%. Tutorial modules for the study of phase equilibrium diagrams. Peh school of pharmaceutical sciences, universiti sains malaysia, 11800 minden, penang, malaysia. Find out more in my free ebook, surfactant science principles and practice, and the apps on practical surfactants. Ternary phase diagram is a very important tool to study the phase behavior of the microemulsion system. Take a wo microemulsion of, say, barium chloride and mix it with a wo microemulsion of, say, sodium sulfate, the two react to create nanoparticles of insoluble baso4.